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Illustrated Health Encyclopedia
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Ency. home > Disease > P > Paget's disease

Paget's disease   

Overview | Symptoms | Treatment

Alternative names:

Osteitis deformans

Treatment

Drug therapy is aimed at suppressing bone breakdown. Currently, there are several classes of medications that inhibit bone resorption and used in the treatment of Paget's disease. These include: bisphosphonates, calcitonin, and plicamycin.

The biphosphonates are the first-line treatment and include the following medications: Etidronate (Didronel), Alendronate (Fosamax), Pamidronate (Aredia), Tiludronate (Skelid), and Risedronate (Actonel). The Calcitonin class includes Intranasal (Miacalcin) and subcutaneous (Calcimar) forms. Plicamycin (Mitrhracin) may also be prescribed. Analgesics or nonsteroidal anti-inflammatory medications (NSAIDS) may be given for pain.

Localized Paget's disease requires no treatment, if there are no symptoms and no evidence of active disease. Orthopedic surgery may be required to correct a specific deformity in severe cases.

Prognosis

Disease activity and symptoms can generally be controlled with current medications. Malignant changes of bone occur in less than 1% of people affected.

Complications

Call Your Health Care Provider If:

Call for an appointment with your health care provider if symptoms of Paget's disease develop.

Ency. home > Disease > P > Paget's disease

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