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Urethritis may be caused by the same organisms that cause bladder or kidney infections (for example, E coli or Klebsiella) and some sexually-transmitted diseases (for example, Chlamydia, gonorrhea, and Ureaplasma urealyticum infections). Urethritis may also develop because of a chemical sensitivity that results in irritation (such as spermatocide in condoms, contraceptive jelly, cream, or foam). Trauma from insertion of an object into the urethra may also cause urethritis. Increased risk is associated with men between 20 and 35 years old, multiple sexual partners, and those who engage in high-risk sexual behavior (such as lack of condom use or anal intercourse).

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