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Ency. home > Disease > P > Primary myelofibrosis

Primary myelofibrosis   

Overview | Symptoms | Treatment | Prevention

Alternative names:

Myelofibrosis; Idiopathic myelofibrosis; Myeloid metaplasia; Agnogenic myeloid metaplasia

Definition:

Primary myelofibrosis is a disorder of the bone marrow in which the marrow is replaced by fibrous (scar) tissue.

Causes and Risks

In primary myelofibrosis, blood formation occurs in sites other than the bone marrow, such as the liver and spleen, causing enlargement of these organs. The cause is unknown. The disorder usually develops slowly in persons over 50 years old. It leads to progressive bone marrow failure with severe anemia. Low platelet count leads to easy bleeding, and spleen enlargement continues. The disease is progressive in most cases. Risk factors are unknown.

Ency. home > Disease > P > Primary myelofibrosis

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