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A detailed history may be required to determine the possible cause of the disorder. Examination and neuromuscular testing may show a specific loss of sensation and movement associated with dysfunction of specific nerves. Reflexes may be abnormal.

Diagnosis of mononeuritis multiplex usually involves deficits of two or more isolated, unrelated nerve areas. Common findings may include:

Sciatic nerve dysfunction
Common peroneal nerve dysfunction
Radial nerve dysfunction
Ulnar nerve dysfunction
Femoral nerve dysfunction
Distal median nerve dysfunction
Axillary nerve dysfunction
Signs of autonomic neuropathy (damage to a part of the nervous system which controls involuntary bodily functions such as the glands and heart)

Tests of nerve conduction velocity usually indicate axonal degeneration. An EMG (test of electrical activity in muscles) may be abnormal. A nerve biopsy may be appropriate for some cases.

Various laboratory tests and procedures may be useful in determining the cause of the condition. Tests are guided by the suspected cause as suggested by the history, symptoms, and pattern of symptom development.

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