Lichen simplex chronicus may be a result of something (such as clothing) that rubs or scratches the skin, or irritation of the skin causing the person to rub or scratch an area. This causes thickening of the skin as a response to chronic irritation. The thickened skin itches, causing more scratching, causing more thickening. The skin may become leathery. The disorder may cause brownish pigmentation of the skin in the lesion area.

This disorder may be associated with atopic dermatitis (eczema) or psoriasis. It may also be associated with nervousness, anxiety, depression, and other psychologic disorders. It can be common in children, who chronically scratch insect bites and other areas. It can also be common in mentally retarded children who have chronic repetitive movements.

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