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Q fever   

Overview | Symptoms | Treatment | Prevention

Alternative names:

Query fever

Definition:

An infection caused by the bacteria Coxiella burnetii which can cause pneumonia and hepatitis (liver inflammation) in its early stage, and infection of the heart valves (endocarditis) in its chronic stage.

Causes and Risks

Q fever is found around the world and is caused by the bacteria Coxiella burnetii. The main reservoirs for Q fever include sheep, goats, cattle, dogs, cats, birds, rodents and ticks, as well as some wild animals. Infected animals shed this bacteria in urine, feces, birth products, and milk. Humans acquire Q fever usually by inhaling contaminated droplets excreted by infected animals. Consumption of raw milk has also been associated with infection in rare cases. People most at risk for this infection are veterinarians, farmers, sheep and dairy workers, as well as laboratory workers who work with this organism.

The incubation period (time to development of symptoms) for early (acute) Q fever is approximately 20 days. In acute Q fever, the 3 main types of syndromes include flu-like syndrome, pneumonia, and hepatitis. Flu-like syndrome is usually self- limited, lasts up to 3 wks, and may involve high fevers, headaches, and muscle aches. Pneumonia can occur in up to a third of individuals -- most cases are relatively mild and include fever and cough, yet some severe cases have been reported. Hepatitis is another common consequence of Q Fever, which can occur alone or with concurrent pneumonia. Other less common features of acute Q fever include rashes, meningitis, myocarditis (inflammation of the heart muscle), and pericarditis (inflammation of heart lining).

Chronic Q fever develops in individuals who have been infected for over 6 months. Its main feature is infection of the heart valves termed endocarditis. Individuals at highest risk include those with underlying heart valve abnormalities, as well as people with weakened immune systems. Other less common features of chronic Q fever are infection of aneurysms, liver dysfunction (cirrhosis), and lung scarring (interstitial pulmonary fibrosis).

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