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Therapeutic drug levels   

Overview | Risks | Results

Alternative names:

Flecainide - serum; Digoxin - serum; Ethosuximide - serum; Disopyramide - serum; Digitoxin - serum; Lidocaine - serum; Kanamycin - serum; Gentamicin - serum; Imipramine - serum; Lithium - serum; Amikacin - serum; Acetaminophen - serum; Aminophylline - serum; TDM; Desipramine - serum; Chloramphenicol - serum; Amitriptyline - serum; Carbamazepine - serum; Methotrexate - serum; Therapeutic drug monitoring; Theophylline - serum; Tobramycin - serum; Valproic acid - serum; Quinidine - serum; Serum drug levels; Salicylate - serum; Propranolol - serum; Phenytoin - serum; Phenobarbital - serum; Procainamide - serum; Primidone - serum; Nortriptyline - serum

Normal Values

Following are some of the drugs that are commonly checked, and their therapeutic levels:

• acetaminophen: varies with use
• amikacin: 15 to 25 mcg/ml
• aminophylline: 10 to 20 mcg/ml
• amitriptyline: 120 to 150 ng/ml
• carbamazepine: 5 to 12 mcg/ml
• chloramphenicol: 10 to 20 mcg/ml
• desipramine: 150 to 300 ng/ml
• digitoxin: 15 to 20 ng/ml
• digoxin: 0.8 to 2.0 ng/ml
• disopyramide: 2 to 5 mcg/ml
• ethosuximide: 40 to 100 mcg/ml
• flecainide: 0.2 to 1.0 mcg/ml
• gentamicin: 5 to 10 mcg/ml
• imipramine: 150 to 300 ng/ml
• kanamycin: 20 to 25 mcg/ml
• lidocaine: 1.5 to 5.0 mcg/ml
• lithium: 0.8 to 1.2 mEq/L
• methotrexate: greater than 0.01 mcmol
• nortriptyline: 50 to 150 ng/ml
• phenobarbital: 10 to 30 mcg/ml
• phenytoin: 10 to 20 mcg/ml
• primidone: 5 to 12 mcg/ml
• procainamide: 4 to 10 mcg/ml
• propranolol: 50 to 100 ng/ml
• quinidine: 2 to 5 mcg/ml
• salicylate: 100 to 250 mcg/ml
• theophylline: 10 to 20 mcg/ml
• tobramycin: 5 to 10 mcg/ml
• valproic acid: 50 to 100 mcg/ml

Note:

• mcg/ml = microgram per milliliter
• ng/ml = nanogram per milliliter
• mEq/L = milliequivalents per liter
• mcmol = micromole

What Abnormal Results Mean

Following are some of the drugs that are commonly checked, and their toxic levels:

• acetaminophen: greater than 250 mcg/ml
• amikacin: greater than 25 mcg/ml
• aminophylline: greater than 20 mcg/ml
• amitriptyline: greater than 500 ng/ml
• carbamazepine: greater than 12 mcg/ml
• chloramphenicol: greater than 25 mcg/ml
• desipramine: greater than 500 ng/ml
• digitoxin: greater than 25 ng/ml
• digoxin: greater than 2.4 ng/ml
• disopyramide: greater than 5 mcg/ml
• ethosuximide: greater than 100 mcg/ml
• flecainide: greater than 1.0 mcg/ml
• gentamicin: greater than 12 mcg/ml
• imipramine: greater than 500 ng/ml
• kanamycin: greater than 35 mcg/ml
• lidocaine: greater than 5 mcg/ml
• lithium: greater than 2.0 mEq/L
• methotrexate: greater than 10 mcmol over 24-hours
• nortriptyline: greater than 500 ng/ml
• phenobarbital: greater than 40 mcg/ml
• phenytoin: greater than 30 mcg/ml
• primidone: greater than 15 mcg/ml
• procainamide: greater than 16 mcg/ml
• propranolol: greater than 150 ng/ml
• quinidine: greater than 10 mcg/ml
• salicylate: greater than 300 mcg/ml
• theophylline: greater than 20 mcg/ml
• tobramycin: greater than 12 mcg/ml
• valproic acid: greater than 100 mcg/ml

Note:

• mcg/ml = microgram per milliliter
• ng/ml = nanogram per milliliter
• mEq/L = milliequivalents per liter
• mcmol = micromole

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