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Ency. home > Test > C > CSF VDRL test

CSF VDRL test   

Overview | Risks | Results

Alternative names:

Venereal Disease Research Laboratory slide test - CSF

Definition:

The CSF-VDRL test is used to diagnose neurosyphilis (syphilis associated with brain or neurologic involvement). This test detects the presence of  reaginic antibodies in cerebrospinal fluid (CSF),  which is the fluid that surrounds the spinal cord and brain.

How the Test is Performed

The test is performed on a cerebrospinal fluid (CSF) sample obtained by lumbar puncture (spinal tap).

How to Prepare for the Test

The procedure to be done is a lumbar puncture (spinal tap).  Before the procedure - you will be asked to sign a consent form after reviewing the risks of this test.  After the lumbar puncture is done, you will be asked to remain lying down flat for 6 hours.

Infants and children:
The physical and psychological preparation you can provide for this or any test or procedure depends on your child's age, interests, previous experiences, and level of trust. For specific information regarding how you can prepare your child, see the following topics as they correspond to your child's age:

How the Test will Feel

You will be asked to lie on your side in the fetal position with your legs curled towards your chest. The area where the needle will be inserted (in your lower back) will be thoroughly cleaned. The scrub will feel cold and wet. You will then receive an injection at the site with local anesthesia which may  sting or burn when first injected. There will be a hard pressure sensation when the needle is inserted, and there is usually some brief pain as the needle goes through. This pain should stop in a few seconds. Overall, discomfort is mild  to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

Why the Test is Performed

The CSF-VDRL test is used to test for syphilis in the brain and/or spinal cord. As this usually reflects late (tertiary) syphilis, the blood screening tests such as VDRL or RPR may be falsely negative.

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